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Estrogen and Serotonin Pathways

Meaning

Estrogen and Serotonin Pathways describe the complex, interconnected neuroendocrine systems where the steroid hormone estrogen exerts a significant modulatory influence on the synthesis, transport, and receptor activity of the neurotransmitter serotonin. This clinical concept is particularly relevant in understanding mood regulation, sleep architecture, and cognitive function, especially in women during periods of hormonal fluctuation like the perimenopause. A balanced interaction between these two pathways is essential for maintaining psychological well-being and homeostatic stability.