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Estrogen and Neuroprotection

Meaning

Estrogen and Neuroprotection describes the crucial and well-documented role that estrogen hormones, particularly the potent 17-beta estradiol, play in preserving the structural integrity, functional capacity, and overall resilience of the central nervous system against various forms of injury, disease, and age-related decline. Estrogen functions as a potent, pleiotropic neuromodulator and neurotrophic factor, actively supporting synaptic plasticity, promoting neuronal survival, and enhancing global cognitive function, especially within the female brain. This protective effect highlights the clinical importance of maintaining adequate and balanced estrogenic signaling for long-term brain health and for mitigating the progressive risk of neurodegenerative conditions.