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Estrogen and Inflammation

Meaning

Estrogen and Inflammation refers to the intricate, bidirectional relationship between estrogenic hormones and the body’s systemic inflammatory response, a critical intersection in human physiology. Estrogen, particularly estradiol, typically exhibits anti-inflammatory properties, helping to maintain endothelial health and modulate immune cell function. However, the precise effect is concentration- and receptor-dependent, as certain estrogen metabolites or high concentrations can sometimes promote pro-inflammatory states. This complex interplay influences the risk and progression of numerous chronic diseases, including cardiovascular and autoimmune conditions, directly linking hormonal balance to overall wellness.