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Estrogen and Fluid Retention

Meaning

Estrogen and Fluid Retention refers to the physiological phenomenon where elevated levels of estrogen, particularly estradiol, influence renal function leading to an increased reabsorption of sodium and water by the kidneys, resulting in noticeable fluid accumulation in tissues. This common clinical observation manifests as edema, often reported by women during the high-estrogen phase of the menstrual cycle or when undergoing certain forms of hormone replacement therapy. It is a key side effect that requires careful clinical management and dosage adjustment.