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Estrobolome Regulation

Meaning

Estrobolome regulation refers to the intrinsic physiological process by which the gut microbiome naturally maintains a stable equilibrium in the metabolism and enterohepatic circulation of estrogens within the body. This homeostatic mechanism ensures that estrogens, following hepatic metabolism, are appropriately deactivated and prepared for excretion, while simultaneously preventing excessive reabsorption of active, unbound forms from the intestinal tract. Efficient regulation is fundamental for maintaining overall hormonal balance, particularly in reproductive and breast health.