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Estradiol Valerate

Meaning

Estradiol Valerate is a synthetic ester of the naturally occurring estrogen, 17-beta estradiol (E2), utilized as a pharmaceutical agent in hormone replacement therapy and for fertility treatments. The addition of the valerate group to the 17-beta hydroxyl position of the estradiol molecule modifies its solubility and pharmacokinetics, allowing for a slower, more sustained release of active estradiol following administration, particularly via intramuscular injection or oral ingestion. Clinically, it is valued for its ability to provide stable, predictable serum estradiol levels over an extended period. This stability contributes to better symptom management and fewer hormonal fluctuations.