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Estradiol-to-Estrone Ratio

Meaning

The Estradiol-to-Estrone Ratio (E2:E1 ratio) is a clinical metric that compares the circulating concentration of the potent estrogen, estradiol (E2), to the less potent estrogen, estrone (E1). This ratio provides insight into the overall metabolic activity of estrogen in the body, particularly the balance of activation and inactivation pathways. A lower ratio may indicate a shift toward less active estrogenic states, which has implications for bone health and menopausal symptom management. This quantitative measure is an important tool in hormonal risk assessment.