Skip to main content

Estradiol Surge

Meaning

The Estradiol Surge is a critical, rapid, and significant increase in the circulating concentration of estradiol (E2), the most potent natural estrogen, that occurs during the late follicular phase of the female menstrual cycle. This pronounced hormonal spike is a physiological event of paramount importance, acting as the definitive positive feedback signal to the hypothalamic-pituitary unit. The surge in estradiol must reach a specific concentration threshold and be sustained for a sufficient duration to effectively trigger the subsequent massive release of luteinizing hormone (LH). This cascade is essential for ovulation, as it culminates in the release of a mature egg from the dominant ovarian follicle.