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Estradiol Signalling Integration

Meaning

Estradiol signaling integration describes the holistic and coordinated way the hormone estradiol (E2) communicates with various tissues throughout the body, mediating its effects on reproductive, cardiovascular, skeletal, and neurocognitive systems. This concept emphasizes that E2’s biological impact is not isolated but rather depends on the expression and function of its specific receptors and the downstream molecular crosstalk in diverse cell types. Maintaining this integration is central to women’s hormonal health and longevity.