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Estradiol Receptor Epigenetics

Meaning

Estradiol Receptor Epigenetics refers to the heritable, non-sequence-based modifications to DNA and associated chromatin proteins that critically regulate the expression and functional activity of the Estrogen Receptor (ER) genes, specifically ER-alpha and ER-beta. These modifications, such as DNA methylation and histone acetylation, dictate the availability of functional receptors within a cell, thereby controlling its sensitivity and magnitude of response to the hormone estradiol. This regulatory layer is paramount for understanding tissue-specific estrogenic effects across metabolic, reproductive, and skeletal health.