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Estradiol Ratio Maintenance

Meaning

Estradiol Ratio Maintenance is the clinical objective of preserving a physiologically appropriate balance between circulating estradiol (E2) and other sex hormones, such as testosterone or progesterone, particularly in hormone replacement therapy. Estradiol, the most potent endogenous estrogen, must be managed carefully to avoid both deficiency and excess, which can manifest as adverse symptoms or increased health risks. For men, this means preventing excessive aromatization of testosterone, while for women, it often involves ensuring an adequate E2 level relative to other hormones for bone, cardiovascular, and cognitive health.