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Estradiol Plasticity Modulation

Meaning

Estradiol Plasticity Modulation is the direct influence of the steroid hormone estradiol (E2), the most potent estrogen, on the brain’s capacity for structural and functional change, known as neuroplasticity. This modulation specifically involves the hormone’s ability to promote synaptogenesis, dendritic arborization, and neuronal survival, particularly within regions like the hippocampus and prefrontal cortex, which are critical for memory and executive function. Optimal estradiol levels are therefore essential for maintaining cognitive reserve and protecting against age-related neurodegeneration, especially in the female brain.