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Estradiol Optimization

Meaning

Estradiol optimization is the clinical strategy of adjusting endogenous or exogenous hormone levels to maintain circulating estradiol (E2) within a range that supports optimal physiological function and overall well-being. Estradiol, the most potent natural estrogen, is crucial not only for female reproductive health but also for bone density, cardiovascular integrity, neuroprotection, and metabolic regulation in both sexes. Optimization involves careful titration of hormonal therapies, such as testosterone replacement or menopausal hormone therapy, to avoid the risks associated with both estrogen deficiency and excess. This personalized approach is guided by sensitive lab assays and clinical symptom assessment.