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Estradiol Neuromodulation

Meaning

Estradiol Neuromodulation refers to the diverse, powerful, and widespread actions of the primary endogenous estrogen, Estradiol (E2), on the structure, function, and chemical signaling of both neurons and supportive glial cells throughout the entire central nervous system. As a potent steroid hormone, E2’s influence extends far beyond its classical reproductive roles; it exerts significant, measurable effects on complex cognitive function, emotional stability, and direct neuroprotection. Understanding this crucial neuromodulatory role is vital for comprehensive clinical management of cognitive health, especially during periods of significant hormonal transition like menopause.