What is the Origin of Estradiol Mortality Curve?

This is a clinical epidemiology term, combining the key hormone "Estradiol" with the "Mortality Curve" concept, which is used to graphically represent risk across a spectrum of biological values. The curve's significance emerged from large-scale longitudinal studies in both men and women, highlighting the profound systemic protective role of E2 beyond its reproductive function.

What is the Mechanism of Estradiol Mortality Curve?

Estradiol exerts its systemic influence by binding to estrogen receptors (ERα and ERβ) in numerous non-reproductive tissues, including the cardiovascular system, brain, and bone. Levels that fall outside the optimal range disrupt critical homeostatic functions, such as vascular tone regulation, healthy lipid metabolism, and inflammation control. The increased mortality observed at the extremes of the curve is thus a reflection of cumulative systemic pathology resulting from chronic E2 dysregulation.

Estradiol Mortality Curve ∞ Area

Estradiol Mortality Curve

Meaning

The Estradiol Mortality Curve refers to the observed statistical relationship between circulating levels of the hormone estradiol (E2) and all-cause mortality risk in human populations. Research suggests a non-linear, typically U-shaped or J-shaped curve, indicating that both very low and excessively high estradiol concentrations are associated with an increased risk of adverse health outcomes and reduced longevity. Optimal health and survival reside within a specific mid-range concentration.