Skip to main content

Estradiol Increase

Meaning

Estradiol increase refers to an elevation in the circulating or local tissue concentration of 17β-estradiol (E2), the most potent naturally occurring estrogen. In a clinical context, this increase can be a physiological event, such as during the follicular phase of the menstrual cycle, or a therapeutic goal in hormone replacement therapy for menopausal individuals. Conversely, an excessive or unphysiological increase may signal a pathological condition, such as certain tumors or an imbalance in aromatase activity. Monitoring this increase is crucial due to estradiol’s potent effects on bone density, cardiovascular function, and proliferative tissues like the endometrium and breast.