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Estradiol Estrone Ratio

Meaning

The Estradiol Estrone Ratio is a clinical metric that quantifies the relative proportion of the two primary circulating estrogens, estradiol (E2) and estrone (E1), typically measured in serum or urine. Estradiol is the most potent estrogen, primarily produced by the ovaries, while estrone is a less potent form, predominantly generated in peripheral tissues like fat cells. This ratio is a critical indicator of estrogenic activity and metabolic balance, providing valuable insight into a patient’s overall hormonal milieu, particularly in peri- and post-menopause. An altered ratio can reflect shifts in aromatase activity and may be relevant for assessing hormone-sensitive tissue health.