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Estradiol and Cognition

Meaning

Estradiol and Cognition refers to the intricate relationship between the primary endogenous estrogen, 17beta-estradiol (E2), and its profound influence on various higher-order brain functions, including memory, executive function, and attention. This relationship is a critical area of study in endocrinology and neuroscience, particularly concerning the female lifespan and hormonal transitions like menopause. Optimal estradiol levels are understood to support neuronal health and synaptic plasticity in key brain regions. Declines in this hormone are clinically associated with subjective cognitive complaints and measurable changes in brain function.