Dietary lipids, specifically linoleic acid (LA, an omega-6) and alpha-linolenic acid (ALA, an omega-3), that the human body cannot synthesize de novo and must obtain exogenously for critical structural and signaling roles. These precursors are indispensable for maintaining cellular membrane fluidity and the synthesis of eicosanoids, which heavily influence inflammatory and hormonal cascades.
Origin
Terminology established in nutritional science, highlighting dietary components necessary for life that are absent from endogenous synthesis pathways. Their importance in hormonal health relates to their role as building blocks for lipid-soluble signaling molecules.
Mechanism
Essential fatty acids serve as substrates for the synthesis of prostaglandins, thromboxanes, and leukotrienes, potent local mediators that modulate local tissue responses to systemic hormones. Furthermore, the integrity of cell membranes, where many steroid receptors reside, is directly dependent on the correct incorporation of these fatty acids. Insufficient intake compromises receptor function and downstream signaling fidelity.
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