Question 1

What is the Meaning of Erythroferrone?

Accepted Answer

Erythroferrone is a recently characterized circulating hormone, a member of the erythroid-derived factors, primarily synthesized and released by erythroblasts, which are the precursor cells for red blood cells, within the bone marrow. Its main function is to communicate the body's iron demand by suppressing the production of hepcidin, the master regulator of systemic iron balance. This hormone is a key physiological link between the need for new red blood cell production and the availability of iron stores.

Question 2

What is the Origin of Erythroferrone?

Accepted Answer

The hormone was formally identified in 2014, and its name is a portmanteau combining 'erythro,' referring to the erythroid lineage of cells, and 'ferrone,' indicating its association with iron metabolism. This discovery fundamentally revised the understanding of iron homeostasis and its regulation by erythropoietic activity.

Question 3

What is the Mechanism of Erythroferrone?

Accepted Answer

Erythroferrone secretion is stimulated by erythropoietin, the hormone that signals the bone marrow to ramp up red blood cell synthesis. Once secreted, erythroferrone travels to the liver where it directly inhibits the transcription of the HAMP gene, thereby reducing hepcidin production. The resulting decrease in hepcidin leads to the preservation of ferroportin on cell surfaces, which in turn facilitates the release of stored iron from macrophages and enhances the absorption of dietary iron from the gut.

Erythroferrone

Meaning

Origin

Mechanism

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