Skip to main content

ERβ Activation

Meaning

ERβ Activation refers to the selective binding and subsequent stimulation of the Estrogen Receptor Beta (ERβ), one of the two main types of estrogen receptors found throughout the body. This activation initiates a cascade of intracellular signaling events that primarily mediate anti-proliferative, anti-inflammatory, and neuroprotective effects, often counterbalancing the proliferative actions associated with the Estrogen Receptor Alpha (ERα). Clinically, selective ERβ modulation is a target for promoting tissue health in organs like the brain, bone, and colon, and for supporting a balanced estrogenic environment.