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ERα/ERβ Signaling

Meaning

ERα/ERβ Signaling refers to the distinct intracellular communication pathways mediated by the two primary subtypes of the estrogen receptor: Estrogen Receptor alpha (ERα) and Estrogen Receptor beta (ERβ). These nuclear receptors act as ligand-activated transcription factors, binding to estrogen and subsequently modulating gene expression in target cells throughout the body. The specific physiological outcome of estrogen action is determined by the relative expression and activation of these two receptor subtypes within a given tissue, as they often mediate opposing biological effects. Understanding the balance between ERα and ERβ signaling is fundamental to precision endocrinology and tissue-specific hormone therapy.