Epithalon Peptide is a synthetic tetrapeptide, specifically Ala-Glu-Asp-Gly, derived from a naturally occurring pineal gland polypeptide, Epithalamin. This molecule is studied extensively for its potential geroprotective and regulatory effects on the endocrine system. Clinically, it is investigated for its capacity to normalize melatonin production, regulate the circadian rhythm, and potentially extend telomere length. Its primary role appears to be a bioregulator, exerting broad influence over neuroendocrine and immune functions crucial for systemic health and aging.
Origin
The peptide’s origin is distinctly Russian biogerontology, where it was developed and extensively researched by Professor Vladimir Khavinson and his team at the Saint Petersburg Institute of Bioregulation and Gerontology. The name is a contraction of the pineal gland region from which its parent compound is extracted, the epithalamus. The classification as a “peptide” simply denotes its short chain of amino acids, solidifying its identity within molecular endocrinology.
Mechanism
The mechanism of Epithalon is multifaceted, primarily involving the stimulation of the pineal gland’s function and the subsequent normalization of the secretion of melatonin. Critically, it has been shown to activate telomerase, the enzyme responsible for maintaining telomere length, thereby potentially mitigating cellular senescence. By restoring the rhythmic function of the pineal gland, it indirectly modulates the entire neuroendocrine axis, impacting cortisol, gonadotropins, and overall circadian homeostasis, contributing to anti-aging effects.
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