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Epigenetic Timing Calibration

Meaning

Epigenetic Timing Calibration refers to the process of fine-tuning the epigenetic modifications, such as DNA methylation and histone acetylation, that regulate the expression patterns of core clock genes and their downstream targets across various tissues. This calibration is essential for maintaining the synchronized and age-appropriate timing of gene expression, which governs cellular function and overall health span. Clinical interventions in this area aim to restore youthful or optimal gene expression patterns by influencing these regulatory marks.