What is the Origin of Epigenetic Timeline?

The concept combines "epigenetic," referring to heritable changes in gene function not caused by changes in DNA sequence, and "timeline," indicating the progression of these changes over an organism's lifespan. The formal development of the epigenetic clock originated from computational biology and bioinformatics, identifying specific CpG sites whose methylation status correlates strongly with chronological age.

What is the Mechanism of Epigenetic Timeline?

The timeline operates by analyzing the methylation status at a defined set of CpG sites across the genome, which collectively form the "clock." DNA Methyltransferases (DNMTs) and demethylases dynamically regulate the methylation marks in response to internal and external stimuli. The specific patterns of hypo- or hyper-methylation at these loci change systematically with age. Algorithms then use these patterns to calculate a biological age, which can be interpreted clinically as a measure of the rate of aging and the efficacy of longevity interventions.

Epigenetic Timeline

Meaning

The Epigenetic Timeline, often referred to clinically as an “epigenetic clock,” is a quantitative measure that estimates an individual’s biological age based on the accumulation of specific DNA methylation changes over time. This metric provides a molecular assessment of aging that is often distinct from chronological age, offering a sophisticated proxy for health span and disease risk. It reflects the cumulative impact of genetic predispositions and environmental factors on gene expression throughout life.

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How Long Does It Take for Lifestyle Changes to Epigenetically Affect Hormones?

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