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Epigenetic Stress Adaptation

Meaning

Epigenetic Stress Adaptation refers to the heritable or semi-heritable modifications to gene expression that occur in response to chronic environmental or psychological stressors, all without altering the underlying DNA nucleotide sequence. These adaptive changes, which include specific patterns of DNA methylation or histone modification, allow the organism to rapidly adjust its physiological set points and responses to persistent stress exposure. In the context of hormonal health, these adaptations can profoundly influence the long-term set points of the Hypothalamic-Pituitary-Adrenal (HPA) axis and fundamental metabolic function. Understanding this mechanism is crucial for developing interventions that can effectively reset maladaptive stress responses.