A comprehensive clinical strategy focused on influencing the non-genetic modifications to DNA and its associated proteins that regulate gene expression without altering the underlying DNA sequence. This management involves optimizing environmental and nutritional factors to positively modulate methylation patterns, histone modifications, and non-coding RNA activity. The goal is to silence pro-aging or disease-associated genes while promoting the expression of genes linked to cellular repair and longevity.
Origin
This concept emerged from the field of epigenetics, a rapidly evolving area of molecular biology that bridges genetics and environmental influence. ‘Signal management’ refers to the therapeutic control exerted over these regulatory layers, acknowledging that lifestyle choices are powerful determinants of gene function.
Mechanism
The core mechanism revolves around supplying the necessary cofactors and substrates for DNA methyltransferases and histone-modifying enzymes, such as specific B vitamins and amino acids. By ensuring proper metabolic input, the fidelity of the epigenetic machinery is maintained, allowing for accurate and youthful gene expression patterns. Effective management helps to reverse age-related epigenetic drift and restore cellular identity.
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