Epigenetic Optimization Peptides are short chains of amino acids designed to influence gene expression without altering the underlying DNA sequence. These compounds specifically target epigenetic mechanisms, such as DNA methylation or histone modification, to promote a more youthful and resilient cellular phenotype. Their therapeutic application aims to optimize the expression of genes associated with longevity, metabolic health, and tissue repair.
Origin
This term merges the fields of peptide therapeutics and epigenetics, a relatively new frontier in molecular biology that studies heritable changes in gene function that do not involve changes to the DNA sequence. The development of synthetic and bio-identical peptides capable of precise signaling has allowed for targeted modulation of the epigenome, offering a novel approach to health span extension.
Mechanism
The peptides function by binding to specific receptors or interacting directly with epigenetic regulatory enzymes, acting as molecular signals to modify chromatin structure. For example, some peptides may enhance the expression of sirtuin genes, which are linked to cellular stress resistance and DNA repair. By selectively turning on or off specific genetic pathways, these molecules promote cellular health and restore functional capacity that may have declined with chronological aging.
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