What is the Origin of Epigenetic Information Transfer?

The term is derived from 'epigenetics,' coined by Conrad Waddington, combining the Greek epi- (on, above) with 'genetics,' to denote mechanisms operating "above" the gene sequence. 'Information transfer' emphasizes the heritable nature of these regulatory marks, linking environment to cellular memory.

What is the Mechanism of Epigenetic Information Transfer?

This transfer is mechanistically driven by enzymes that add or remove chemical tags, such as methyl groups, to DNA or alter the structure of histone proteins around which DNA is wound. These modifications dictate whether a gene is accessible for transcription, thereby controlling the synthesis of regulatory proteins and hormones. Lifestyle factors can profoundly influence these epigenetic marks, demonstrating a powerful link between environment and the manifestation of genetic potential.

Epigenetic Information Transfer ∞ Area

Epigenetic Information Transfer

Meaning

Epigenetic Information Transfer is the process by which non-DNA sequence-based information, such as DNA methylation and histone modification patterns, is reliably passed from parent cells to daughter cells, or even across generations, influencing gene expression without altering the underlying genetic code. This dynamic mechanism serves as a crucial interface between environmental factors, including nutrition and stress, and the stable regulation of the genome. Understanding this transfer is vital for managing long-term health outcomes and phenotypic expression.