What is the Origin of Epigenetic Information Repair?

This concept arises directly from the rapidly evolving field of epigenetics, which studies how environmental and lifestyle factors can switch genes on or off across generations. The "repair" aspect addresses the known instability of the epigenome over time.

What is the Mechanism of Epigenetic Information Repair?

The mechanism involves supplying necessary cofactors—like methyl donors or acetyl groups—that influence the activity of epigenetic modifying enzymes such as DNA methyltransferases or histone acetyltransferases. By modulating these enzymatic activities, we can promote the re-expression of beneficial genes previously silenced by aging or stress.

Epigenetic Information Repair ∞ Area

Epigenetic Information Repair

Meaning

Epigenetic Information Repair refers to interventions that influence the molecular mechanisms controlling gene expression without altering the underlying DNA sequence itself. This involves correcting detrimental epigenetic drift, such as aberrant DNA methylation or histone modification patterns, that accumulate with age. We aim to restore youthful transcriptional patterns.