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Epigenetic Gene Regulation

Meaning

Epigenetic gene regulation refers to heritable changes in gene expression that occur without altering the underlying DNA sequence, profoundly influencing cellular identity and function. These regulatory mechanisms include DNA methylation, histone modification, and non-coding RNA mechanisms, acting as crucial intermediaries between environmental factors and the genome. In the context of hormonal health, epigenetic changes can modulate the expression of hormone receptors or steroidogenic enzymes, thereby altering a tissue’s sensitivity or capacity for hormonal response. Understanding this regulation is key to comprehending the long-term impact of lifestyle and environment on health and longevity.