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Epigenetic Fuel Signaling

Meaning

Epigenetic Fuel Signaling refers to the dynamic intersection where cellular nutrient status and metabolic intermediates directly influence the epigenetic machinery, thereby altering gene expression without changing the underlying DNA sequence. This concept highlights how the availability of metabolic “fuel,” such as glucose, fatty acids, and key cofactors, acts as a signaling mechanism that regulates chromatin structure and transcriptional activity. It represents a crucial biological link between diet, metabolism, and long-term genomic health.