A cutting-edge therapeutic goal focused on restoring the youthful, correct patterns of gene regulation that become disorganized and aberrant with age, a process termed epigenetic drift. This reversal aims to reset the cellular memory and transcriptional landscape to a more robust, less error-prone state. It is a core strategy in biological age reduction and longevity medicine.
Origin
The term is rooted in epigenetics, the study of heritable changes in gene function that do not involve changes in the DNA sequence itself. Drift describes the random, age-associated loss of fidelity in these patterns, and reversal is the clinical ambition to correct these accumulated errors.
Mechanism
Reversal is mediated by interventions that influence DNA methylation and histone modifications, which are the primary epigenetic marks. Agents, including specific small molecules or cofactors, can act as modulators for methyltransferases and demethylases to erase pathological marks and reinforce beneficial ones. By restoring the correct methylation status across the genome, particularly at CpG islands and repetitive elements, the cell’s youthful transcriptional program is re-engaged, leading to improved cellular function and stability.
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