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Epigenetic Damage

Meaning

Epigenetic Damage refers to persistent, often adverse, alterations in the chemical modifications of DNA or associated histone proteins that regulate gene expression without changing the underlying nucleotide sequence itself. Such damage can lead to the inappropriate silencing of protective genes or the aberrant activation of genes linked to pathology, including endocrine disruption. In hormonal health, this mechanism is crucial as environmental factors can directly modify the epigenome controlling hormone receptor function. This concept bridges environmental exposure with long-term physiological programming.