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Epigenetic Confounding

Meaning

Epigenetic Confounding refers to the clinical and research challenge posed by non-genetic, heritable changes in gene expression that can obscure or complicate the interpretation of hormonal health interventions and outcomes. These confounding factors include lifestyle, diet, and environmental exposures that alter DNA methylation or histone modification patterns, independently influencing biological age and disease risk. In a clinical context, these variables must be accounted for to accurately assess the true effect of a targeted hormonal therapy. It highlights the complexity of personalized medicine.