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Epigenetic Clock Validation

Meaning

Epigenetic Clock Validation is the rigorous scientific and clinical process of confirming the accuracy, precision, and functional utility of an epigenetic aging clock, a molecular tool that estimates biological age based on specific DNA methylation patterns. This validation involves comparing the clock’s age prediction against chronological age, established physiological measures of health and frailty, and most importantly, future mortality and morbidity risk across diverse human cohorts. Clinical translation of these clocks relies entirely on this validation to ensure that the reported biological age is a reliable and actionable biomarker for monitoring the effectiveness of longevity and hormonal interventions. A well-validated clock provides objective, quantifiable feedback on the true rate of aging.