Epigenetic Clock Slowing is the clinical objective of decelerating the rate of biological aging as measured by specific, quantifiable patterns of DNA methylation across the genome. The “epigenetic clock” is a biochemical marker that accurately estimates an individual’s biological age, often revealing a significant deviation from chronological age. Achieving this slowing implies a systemic reversal or mitigation of age-related molecular changes, leading to an improved healthspan and a reduced risk of age-associated diseases.
Origin
This term is directly derived from the field of epigenetics and molecular gerontology, following the discovery of highly accurate epigenetic age predictors, such as the Horvath clock. ‘Epigenetic’ refers to heritable changes in gene expression that do not involve alterations to the underlying DNA sequence. The concept has rapidly become a central, measurable metric in longevity research and advanced anti-aging clinical practice.
Mechanism
The core mechanism involves modulating the activity of enzymes like DNA methyltransferases and demethylases to influence the methylation status of specific CpG sites in the DNA. Lifestyle interventions, nutrient co-factors, and targeted small molecules are employed to promote a more youthful methylation pattern. This process ultimately influences gene expression, potentially driving cellular pathways toward repair, maintenance, and reduced cellular senescence.
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