What is the Origin of Epigenetic Clock Reversal?

This term merges epigenetics, the study of heritable changes in gene function that do not involve changes in the DNA sequence itself, with the concept of a biological clock based on methylation marks. Reversal implies an active pushing back against the entropic accumulation of age-related epigenetic drift.

What is the Mechanism of Epigenetic Clock Reversal?

The mechanism involves influencing the activity of DNA methyltransferases (DNMTs) and demethylases, often indirectly through metabolic intermediates. For instance, boosting NAD+ levels supports the activity of Sirtuins, which can influence the epigenetic landscape towards a more youthful state. Successful reversal means optimizing the cellular environment so that critical longevity genes are expressed appropriately, overriding accumulated age-related silencing marks.

Epigenetic Clock Reversal

Meaning

Epigenetic Clock Reversal is the biological phenomenon where interventions successfully reduce an individual’s estimated epigenetic age, as calculated from DNA methylation patterns, below their actual chronological age. This reversal suggests a restoration of youthful gene expression patterns, often correlating with improved cellular function and reduced senescence burden. Clinically, achieving this reversal is a powerful indicator of effective anti-aging or longevity strategies. We are aiming to rewind the molecular expression of time.