Epigenetic Clock Management involves actively influencing DNA methylation patterns across the genome to slow the rate at which an individual’s biological age advances relative to their chronological age. This practice seeks to preserve the youthful expression profile of key longevity genes. Effective management aims for a deceleration of cellular aging markers.
Origin
This field stems directly from the discovery of epigenetic clocks, such as the Horvath clock, which use specific CpG site methylation status to estimate biological age. Management strategies integrate nutritional science and lifestyle modification informed by these molecular insights.
Mechanism
Management strategies often modulate epigenetic machinery via nutrient cofactors, such as B vitamins or S-adenosylmethionine (SAMe), which are essential for methylation reactions. By optimizing the cellular environment, we aim to direct DNA methyltransferases to maintain methylation patterns associated with younger tissue states, thereby influencing gene expression favorably.
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