What is the Origin of Epigenetic Clock Deceleration?

This concept is derived from the field of epigenetics, which studies heritable changes in gene expression that do not involve alterations to the underlying DNA sequence. The 'clock' metaphor was developed to track cumulative age-related epigenetic drift. Deceleration represents a successful intervention against this drift.

What is the Mechanism of Epigenetic Clock Deceleration?

Deceleration is hypothesized to occur through interventions that enhance cellular repair mechanisms and improve epigenetic regulator function. Key pathways involve optimizing NAD+ availability to fuel sirtuins, which act as deacetylases influencing chromatin structure. Furthermore, reducing chronic inflammation lessens the burden on DNA repair machinery, preserving methylation fidelity.

Epigenetic Clock Deceleration

Meaning

The slowing of biological aging as measured by specific epigenetic markers, most notably DNA methylation patterns used in validated aging clocks like Horvath or Hannum clocks. Deceleration indicates a shift toward a more youthful molecular profile, potentially extending healthspan. This is a quantifiable metric of biological age relative to chronological age.