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Epigenetic Biological Age Clocks

Meaning

Epigenetic Biological Age Clocks are sophisticated mathematical models that estimate an individual’s biological age, or ‘epigenetic age,’ by analyzing the methylation status of specific cytosine-guanine dinucleotide (CpG) sites across the genome. Unlike chronological age, which is fixed, this biological age reflects the cumulative impact of genetic, environmental, and lifestyle factors on the organism’s physiological state. Clinically, these clocks serve as advanced biomarkers for predicting healthspan, disease risk, and the effectiveness of longevity and hormonal interventions. They provide a quantitative measure of the pace of aging.