What is the Origin of Epigenetic Age Assessment?

The concept originated from landmark research in molecular biology, notably the work of Steve Horvath, which demonstrated a strong correlation between DNA methylation patterns and age across diverse tissues. This methodology leverages the field of epigenetics, which studies heritable changes in gene expression that occur without altering the primary DNA sequence.

What is the Mechanism of Epigenetic Age Assessment?

The assessment operates by analyzing the degree of methylation—the addition of a methyl group to a cytosine base—at specific CpG islands in the genome. Certain methylation patterns are consistently associated with chronological age and are believed to reflect the cumulative effect of environmental and genetic factors on the aging process. The resulting "age" calculation provides a functional measure of cellular and systemic wear and tear.

Epigenetic Age Assessment ∞ Area

Epigenetic Age Assessment

Meaning

Epigenetic Age Assessment is a molecular diagnostic technique that quantifies an individual’s biological age by measuring patterns of DNA methylation across specific genomic sites, often referred to as an “epigenetic clock.” This assessment provides a metric of aging that is independent of chronological age, offering a precise, dynamic biomarker of healthspan and longevity. It is a powerful tool for monitoring the biological impact of lifestyle and therapeutic interventions.