Skip to main content

Epicardial Activation

Meaning

Epicardial Activation, in a hormonal health context, refers to the process where the epicardium, the outermost layer of the heart, transitions from a quiescent state to an active, progenitor-like state following cardiac injury. This activation is a key step in the heart’s intrinsic, though often insufficient, attempt at regeneration and repair, involving cellular proliferation and migration. Recent research highlights that this regenerative response is significantly modulated by neuroendocrine signaling, establishing a direct link between the hormonal system and myocardial repair mechanisms.