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Enzalutamide Resistance

Meaning

Enzalutamide Resistance is the clinical state in which prostate cancer cells, initially responsive to the potent androgen receptor inhibitor enzalutamide, develop mechanisms to circumvent its therapeutic effect, leading to disease progression. Enzalutamide is a second-generation anti-androgen designed to block androgen receptor signaling at multiple steps, including ligand binding, nuclear translocation, and DNA binding. The emergence of resistance signifies a critical point in the disease trajectory, often resulting in castration-resistant prostate cancer (CRPC) that requires a change in systemic therapy. Understanding the resistance mechanisms is paramount for designing subsequent precision oncology treatments.