What is the Origin of Enzalutamide?

Enzalutamide is a pharmaceutical name, a non-proprietary drug name designated by the World Health Organization. It belongs to the class of second-generation anti-androgens, developed through medicinal chemistry efforts focused on overcoming resistance mechanisms.

What is the Mechanism of Enzalutamide?

The drug acts primarily by binding to the androgen receptor (AR) with high affinity, thereby preventing androgen binding and subsequent receptor activation. Crucially, it also inhibits the nuclear translocation of the AR and impairs its DNA binding capability, which are key steps for gene transcription and cancer cell proliferation. This multi-level inhibition significantly reduces the androgen-driven growth of prostate cancer cells.

Enzalutamide ∞ Area

Enzalutamide

Meaning

A non-steroidal anti-androgen medication clinically used in the treatment of prostate cancer, particularly in castration-resistant forms of the disease. It functions as a potent androgen receptor signaling inhibitor, blocking the cellular effects of testosterone and dihydrotestosterone. This therapeutic agent offers a critical option for managing advanced prostate cancer progression.

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Are There Strategies to Mitigate Cognitive Side Effects of Androgen Deprivation?

Strategies for ADT's cognitive effects involve systemic support, like multimodal exercise, to bolster the brain's resilience.

∞ Cognitive Reserve
∞ Androgen Receptor
∞ Multimodal Exercise

HRTioAugust 2, 2025

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How Do Androgen Receptors Influence Prostate Response to Testosterone?

Androgen receptors act as molecular switches that, when activated by testosterone, dictate prostate cell growth, function, and survival.

∞ Growth Factor
∞ AR Gene Amplification
∞ Androgen Receptor

HRTioJuly 25, 2025

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What Are the Clinical Implications of Androgen Receptor Splice Variants in Prostate Cancer?

Androgen receptor variants are cellular adaptations driving treatment resistance, making their detection a key guide for personalizing prostate cancer therapy.

∞ Castration-Resistant Prostate Cancer
∞ Androgen Deprivation
∞ Abiraterone

HRTioJuly 25, 2025

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How Do Androgen Receptor Mutations Affect Prostate Cancer Treatment?

Androgen receptor mutations alter how prostate cancer responds to treatment, often leading to resistance by enabling growth despite low androgen levels.

∞ Androgen Levels
∞ Prostate Cancer
∞ AR Splice Variants

HRTioJuly 19, 2025

Enzalutamide

Meaning

Origin

Mechanism

Are There Strategies to Mitigate Cognitive Side Effects of Androgen Deprivation?

How Do Androgen Receptors Influence Prostate Response to Testosterone?

What Are the Clinical Implications of Androgen Receptor Splice Variants in Prostate Cancer?

How Do Androgen Receptor Mutations Affect Prostate Cancer Treatment?

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