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Enterolignans

Meaning

Enterolignans are biologically active compounds produced in the human gut through the metabolic action of the intestinal microbiota on dietary lignan precursors, which are primarily found in seeds, whole grains, and vegetables. These specific metabolites, principally enterodiol and enterolactone, are classified as phytoestrogens due to their structural similarity to endogenous estrogens, allowing them to exert weak estrogenic or anti-estrogenic effects. Their clinical significance in hormonal health relates to their potential role in modulating estrogen metabolism, which may offer protective effects against hormone-sensitive conditions and support overall metabolic balance. The presence and concentration of enterolignans serve as a biomarker for both gut health and dietary intake.