What is the Origin of Enteroendocrine Hormones?

The term derives from "entero," referring to the intestine, and "endocrine," referring to internal secretion, highlighting their origin in the gut and their function as systemic messengers. The discovery of secretin in the early 20th century, the first hormone ever identified, established the gut as a major endocrine organ. Recognition of the clinical significance of these peptides has accelerated with the development of GLP-1 receptor agonists for type 2 diabetes and obesity management.

What is the Mechanism of Enteroendocrine Hormones?

Upon ingestion of food, enteroendocrine cells sense specific nutrients within the gut lumen, triggering the rapid release of stored hormones into the bloodstream. These hormones then travel to distant target organs, including the pancreas, liver, and brain, to exert their effects. For example, GLP-1 enhances glucose-dependent insulin secretion from pancreatic beta cells, slows gastric emptying, and promotes satiety via central nervous system signaling.

Enteroendocrine Hormones ∞ Area

Enteroendocrine Hormones

Meaning

Enteroendocrine hormones are a diverse group of biologically active peptides secreted by specialized cells, known as enteroendocrine cells, scattered throughout the gastrointestinal tract mucosa. These hormones act as chemical messengers to regulate digestive function, nutrient absorption, and systemic energy balance. They form a critical component of the gut-brain axis, influencing satiety, glucose homeostasis, and insulin secretion. Key examples include Glucagon-like peptide-1 (GLP-1), ghrelin, cholecystokinin (CCK), and peptide YY (PYY), all of which are central to metabolic health.

A woman rests serenely on a horse, reflecting emotional well-being and stress modulation. This symbolizes positive therapeutic outcomes for the patient journey toward hormone optimization, fostering endocrine equilibrium and comprehensive clinical wellness.

Are There Specific Dietary Interventions That Complement Hormonal Support?

Dietary interventions act as precise biological messages, profoundly influencing endocrine system function and supporting metabolic equilibrium for enhanced vitality.

∞ Detoxification Pathways
∞ Aromatization Management
∞ Gut Microbiome Modulation

HRTioAugust 25, 2025

Enteroendocrine Hormones

Meaning

Origin

Mechanism

Are There Specific Dietary Interventions That Complement Hormonal Support?

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