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Enterocyte Fuel

Meaning

Enterocyte Fuel refers to the primary energy substrates utilized by enterocytes, the epithelial cells lining the small and large intestines, to maintain their structural integrity and critical barrier function. The preferred fuel source for colonocytes is the short-chain fatty acid butyrate, while glutamine and glucose are also vital energy sources for small intestinal enterocytes. Adequate and appropriate fuel is paramount for supporting the high metabolic demands of these cells, which are responsible for nutrient absorption and maintaining the intestinal barrier against pathogens and toxins. Insufficient fuel can compromise gut health.