Enteric Nervous System Health refers to the optimal structural integrity and functional capacity of the extensive network of neurons embedded in the wall of the gastrointestinal tract, often termed the “second brain.” This system operates largely autonomously, controlling motility, secretion, and local blood flow, and it maintains a continuous bidirectional communication with the central nervous system. A healthy ENS is crucial for digestive efficiency and systemic neuroendocrine balance.
Origin
The concept stems from neurogastroenterology, where “enteric” refers to the intestines and the “nervous system” describes the collection of specialized nerve cells. The clinical focus on ENS health has intensified with the recognition of the gut-brain axis, highlighting the gut’s profound influence on mood, cognition, and stress response. It is a critical area in integrated human physiology.
Mechanism
The ENS utilizes numerous neurotransmitters, including serotonin and dopamine, to regulate peristalsis and mucosal immune function. Optimal ENS health ensures efficient signaling, preventing dysmotility and minimizing visceral hypersensitivity. Furthermore, a well-functioning ENS is instrumental in modulating the inflammatory response within the gut, which directly influences systemic cytokine levels and, consequently, the peripheral regulation of stress and metabolic hormones.
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