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eNOS Pathway

Meaning

The Endothelial Nitric Oxide Synthase (eNOS) pathway is a crucial biochemical cascade responsible for the synthesis of nitric oxide (NO) within the endothelial cells lining the blood vessels. Nitric oxide is a potent vasodilator and a key signaling molecule that maintains vascular tone, regulates blood pressure, and inhibits platelet aggregation and leukocyte adhesion. This pathway is central to cardiovascular health, and its optimal function is closely tied to hormonal factors, including estrogen and testosterone. Dysfunction in eNOS signaling is a hallmark of endothelial impairment and early cardiovascular disease.